Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

نویسندگان

  • John J Marini
  • John R Hotchkiss
  • Alain F Broccard
چکیده

Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.

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عنوان ژورنال:
  • Critical Care

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2003